A recent study suggests glp 1 receptor agonists may be more likely to cause diabetes patients nausea diarrhea vomiting and other gastrointestinal adverse effects at certain doses and in certain combinations with other medications these findings show that the gastrointestinal adverse effects are according to the study abstract related to dose and background medications especially metformin and may vary in a compound specific manner.
Glp 1 ra side effects.
The most common symptoms associated with the use of glp 1 receptor agonists are gastrointestinal symptoms mainly nausea.
Glp 1 as has a short duration of action so to overcome this limitation several modifications either in the drug or the formulations are being developed.
This usually resolves after a few weeks and many clinicians start the drug at a low dose and titrate up to help decrease or prevent these side effects.
Glp 1 exerts several effects to lower blood glucose levels including stimulating the pancreatic islets to secrete insulin while suppressing the secretion of glucagon.
Glp 1 receptor agonists can cause nausea vomiting diarrhea headache weakness or dizziness.
There is some dispute over the safety profile of these drugs due to proliferative effects in the pancreas.
But the risk of low blood sugar levels is usually only increased if you re taking another medication known to lower blood sugar at the same time such as sulfonylureas or insulin.
The most common side effects of glp 1 ras are injection site reactions nausea and diarrhea because of the slowed gastric emptying.
For example nausea and vomiting with abdominal pain could be pancreatitis inflammation of the pancreas.
Other common adverse effects include injection site reactions headache and nasopharyngitis but these effects do not usually result in discontinuation of the drug.
And at high doses delaying gastric emptying and inducing satiety reduction in food intake while there are many non insulin options used to help manage diabetes glucagon like peptide 1 receptor agonists glp 1ras or glp1s have been a popular topic of discussion due to its once a week convenient dosing and its efficacy.
Diarrhoea nausea vomiting headaches dizziness increased sweating indigestion constipation loss of appetite.
Some side effects are warning signs of serious conditions.
Ask your doctor which signs to watch for and what to do if those signs happen.
Low blood sugar levels hypoglycemia are a more serious risk linked to the glp 1 class of medications.
Feelings of early fullness lower appetite nausea vomiting diarrhea.
Glp 1 was initially thought to primarily affect insulin release.
Glp 1 ras commonly cause digestive side effects such as.
